C<use lib "$ENV{HOME}/perl5/lib/perl5";> inside the script instead of using
C<local::lib> directly.
+=item * Conflicts with L<ExtUtils::MakeMaker>'s C<PREFIX> option.
+C<local::lib> uses the C<INSTALL_BASE> option, as it has more predictable and
+sane behavior. If something attempts to use the C<PREFIX> option when running
+a F<Makefile.PL>, L<ExtUtils::MakeMaker> will refuse to run, as the two
+options conflict. This can be worked around by temporarily unsetting the
+C<PERL_MM_OPT> environment variable.
+
+=item * Conflicts with L<Module::Build>'s C<--prefix> option. Similar to the
+previous limitation, but any C<--prefix> option specified will be ignored.
+
=back
Patches very much welcome for any of the above.